Hepatic
Records checked
Compiled and citation-checked by GLP-1 Receptor Agonists editorial desk
Qualified clinical review None on record
Records whose assigned subject headings cover the liver, hepatic steatosis, fibrosis or the transaminases indexed with them. 9 of the 186 records indexed across this publication's scope carry at least one of them, covering 9 of the 17 compounds.
Assignment is mechanical. A record sits under this endpoint because the indexer attached one of the subject headings listed further down, not because anyone read it. The cell counts records. It does not report a result, a direction or a magnitude, and nothing in the corpus would let it.
Record coverage by compound and record class
| Compound | Ph 3 | Ph 2 | Ph 1 | Trial, no phase | Review | Other | All |
|---|---|---|---|---|---|---|---|
| Amylin | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cagrilintide | 0 | 0 | 0 | 0 | 0 | 1 [3] | 1 |
| Dulaglutide | 0 | 0 | 0 | 1 [8] | 0 | 0 | 1 |
| Eloralintide | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Exenatide | 0 | 0 | 0 | 1 [9] | 0 | 0 | 1 |
| GLP-1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Liraglutide | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Lixisenatide | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Maridebart cafraglutide | 0 | 0 | 0 | 0 | 0 | 1 [1] | 1 |
| Mazdutide | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Orforglipron | 1 [5] | 0 | 0 | 0 | 0 | 0 | 1 |
| Petrelintide | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pramlintide | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Retatrutide | 0 | 0 | 0 | 0 | 0 | 1 [2] | 1 |
| Semaglutide | 1 [6] | 0 | 0 | 0 | 0 | 0 | 1 |
| Survodutide | 1 [4] | 0 | 0 | 0 | 0 | 0 | 1 |
| Tirzepatide | 0 | 1 [7] | 0 | 0 | 0 | 0 | 1 |
Column keys: Ph 3 phase 3; Ph 2 phase 2; Ph 1 phase 1; Trial, no phase trial, no phase assigned; Review review or synthesis; Other not a registered trial record. Phase is read from the publication type the indexer assigned to each record, never from its title.
A zero cell records that no indexed record for that compound carries one of these subject headings. It is the absence of a retrieved report, never the absence of the thing itself. The full record set for each compound is held on its own trial page.
Subject headings that place a record here
The full set is fixed and printed here so the assignment can be checked by hand against the method. 8 of the 8 headings in the set occur on at least one record in scope.
| Subject heading | Records |
|---|---|
| Liver | 8 |
| Fatty Liver | 4 |
| Alanine Transaminase | 2 |
| Liver Cirrhosis | 2 |
| Aspartate Aminotransferases | 1 |
| Liver Diseases | 1 |
| Liver Function Tests | 1 |
| Non-alcoholic Fatty Liver Disease | 1 |
The records
9 distinct records, newest first within each class. A record indexed under more than one compound is listed once and named under each.
Phase 3 — 3 records
| No. | Identifier | Year | Record | Model | Indexed under | Subject headings |
|---|---|---|---|---|---|---|
| 4 | pmid:42252333 | 2026 | Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial Nature medicine · Clinical Trial, Phase III, Randomized Controlled Trial | human trial | Survodutide | Liver; Humans; Fatty Liver; Obesity; Magnetic Resonance Imaging; Body Mass Index; Double-Blind Method; Adult |
| 5 | pmid:42338042 | 2026 | Hepatic Safety of Orforglipron in Adults With Obesity or Overweight and/or Type 2 Diabetes: A Pooled Analysis of the Orforglipron Phase 3 Clinical Trials Diabetes, obesity & metabolism · Clinical Trial, Phase III, research-article | human trial | Orforglipron | Liver; Humans; Diabetes Mellitus, Type 2; Obesity; Fluorine Compounds; Benzhydryl Compounds; Oxadiazoles; Alanine Transaminase |
| 6 | pmid:40305708 | 2025 | Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis The New England journal of medicine · Clinical Trial, Phase III, Multicenter Study | human trial | Semaglutide | Liver; Humans; Liver Cirrhosis; Biopsy; Treatment Outcome; Injections, Subcutaneous; Drug Administration Schedule; Severity of Illness Index |
Phase 2 — 1 record
| No. | Identifier | Year | Record | Model | Indexed under | Subject headings |
|---|---|---|---|---|---|---|
| 7 | pmid:38856224 | 2024 | Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis The New England journal of medicine · Clinical Trial, Phase II, Multicenter Study | human trial | Tirzepatide | Liver; Humans; Fatty Liver; Liver Cirrhosis; Gastric Inhibitory Polypeptide; Injections, Subcutaneous; Double-Blind Method; Dose-Response Relationship, Drug |
Trial, no phase assigned — 2 records
| No. | Identifier | Year | Record | Model | Indexed under | Subject headings |
|---|---|---|---|---|---|---|
| 8 | pmid:32865597 | 2020 | Effect of dulaglutide on liver fat in patients with type 2 diabetes and NAFLD: randomised controlled trial (D-LIFT trial) Diabetologia · Research Support, Non-U.S. Gov't, Randomized Controlled Trial | human trial | Dulaglutide | Liver; Humans; Diabetes Mellitus, Type 2; Alanine Transaminase; Aspartate Aminotransferases; Recombinant Fusion Proteins; Hypoglycemic Agents; Liver Function Tests |
| 9 | pmid:27106272 | 2016 | Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy Diabetes, obesity & metabolism · Randomized Controlled Trial | human trial | Exenatide | Myocardium; Liver; Pancreas; Heart; Pericardium; Adipose Tissue; Venoms; Humans |
Not a registered trial record — 3 records
| No. | Identifier | Year | Record | Model | Indexed under | Subject headings |
|---|---|---|---|---|---|---|
| 1 | pmid:41287212 | 2026 | A metabolic comparison of GIPR agonism versus GIPR antagonism in male mice Diabetes, obesity & metabolism · Comparative Study, research-article | rodent | Maridebart cafraglutide | Liver; Adipose Tissue; Animals; Mice, Inbred C57BL; Mice; Insulin Resistance; Obesity; Body Weight |
| 2 | pmid:41741376 | 2026 | Retatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models Obesity (Silver Spring, Md.) · research-article | rodent | Retatrutide | Liver; Animals; Mice, Inbred C57BL; Mesocricetus; Mice; Mice, Obese; Fatty Liver; Insulin Resistance |
| 3 | pmid:42228334 | 2026 | Renal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide Clinical pharmacokinetics · research-article, Multicenter Study | human trial | Cagrilintide | Humans; Liver Diseases; Hypoglycemic Agents; Injections, Subcutaneous; Area Under Curve; Adult; Aged; Middle Aged |
What this page does not say
- It does not say what any record found. Subject headings describe what a record is about, not what it concluded.
- It does not rank the compounds. The column order is fixed by record class and the row order is alphabetical, neither of which carries a judgement.
- It does not represent the literature. The counts are of records this corpus carries; the queries behind them returned 48,938 records in total across the compounds in scope.
- It is not clinical guidance, and it is not reviewed by a clinician. The disclaimer states the limits in full.