GLP-1 Receptor Agonists

Hepatic

Records checked

Compiled and citation-checked by GLP-1 Receptor Agonists editorial desk

Qualified clinical review None on record

Withheld from the index. This page sets out the indexed clinical-record picture for all 17 compounds in scope, at one endpoint.

Every compound in scope is marked high impact and none has a qualified clinical reviewer recorded, so this page is built, checked and served with a noindex directive and left out of the sitemap. Nothing on it has been removed or softened. Recording a named reviewer publishes it unchanged on the next build. How the gate works.

Records whose assigned subject headings cover the liver, hepatic steatosis, fibrosis or the transaminases indexed with them. 9 of the 186 records indexed across this publication's scope carry at least one of them, covering 9 of the 17 compounds.

Assignment is mechanical. A record sits under this endpoint because the indexer attached one of the subject headings listed further down, not because anyone read it. The cell counts records. It does not report a result, a direction or a magnitude, and nothing in the corpus would let it.

Record coverage by compound and record class

Indexed records carrying a hepatic subject heading, by compound and by the record class assigned to each record. Bracketed numbers are the records themselves, listed below.
CompoundPh 3Ph 2Ph 1Trial, no phaseReviewOtherAll
Amylin0000000
Cagrilintide000001 [3]1
Dulaglutide0001 [8]001
Eloralintide0000000
Exenatide0001 [9]001
GLP-10000000
Liraglutide0000000
Lixisenatide0000000
Maridebart cafraglutide000001 [1]1
Mazdutide0000000
Orforglipron1 [5]000001
Petrelintide0000000
Pramlintide0000000
Retatrutide000001 [2]1
Semaglutide1 [6]000001
Survodutide1 [4]000001
Tirzepatide01 [7]00001

Column keys: Ph 3 phase 3; Ph 2 phase 2; Ph 1 phase 1; Trial, no phase trial, no phase assigned; Review review or synthesis; Other not a registered trial record. Phase is read from the publication type the indexer assigned to each record, never from its title.

A zero cell records that no indexed record for that compound carries one of these subject headings. It is the absence of a retrieved report, never the absence of the thing itself. The full record set for each compound is held on its own trial page.

Subject headings that place a record here

The full set is fixed and printed here so the assignment can be checked by hand against the method. 8 of the 8 headings in the set occur on at least one record in scope.

Subject headingRecords
Liver8
Fatty Liver4
Alanine Transaminase2
Liver Cirrhosis2
Aspartate Aminotransferases1
Liver Diseases1
Liver Function Tests1
Non-alcoholic Fatty Liver Disease1

The records

9 distinct records, newest first within each class. A record indexed under more than one compound is listed once and named under each.

Phase 3 — 3 records

No.IdentifierYearRecordModelIndexed underSubject headings
4pmid:422523332026Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial
Nature medicine · Clinical Trial, Phase III, Randomized Controlled Trial
human trialSurvodutideLiver; Humans; Fatty Liver; Obesity; Magnetic Resonance Imaging; Body Mass Index; Double-Blind Method; Adult
5pmid:423380422026Hepatic Safety of Orforglipron in Adults With Obesity or Overweight and/or Type 2 Diabetes: A Pooled Analysis of the Orforglipron Phase 3 Clinical Trials
Diabetes, obesity & metabolism · Clinical Trial, Phase III, research-article
human trialOrforglipronLiver; Humans; Diabetes Mellitus, Type 2; Obesity; Fluorine Compounds; Benzhydryl Compounds; Oxadiazoles; Alanine Transaminase
6pmid:403057082025Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis
The New England journal of medicine · Clinical Trial, Phase III, Multicenter Study
human trialSemaglutideLiver; Humans; Liver Cirrhosis; Biopsy; Treatment Outcome; Injections, Subcutaneous; Drug Administration Schedule; Severity of Illness Index

Phase 2 — 1 record

No.IdentifierYearRecordModelIndexed underSubject headings
7pmid:388562242024Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis
The New England journal of medicine · Clinical Trial, Phase II, Multicenter Study
human trialTirzepatideLiver; Humans; Fatty Liver; Liver Cirrhosis; Gastric Inhibitory Polypeptide; Injections, Subcutaneous; Double-Blind Method; Dose-Response Relationship, Drug

Trial, no phase assigned — 2 records

No.IdentifierYearRecordModelIndexed underSubject headings
8pmid:328655972020Effect of dulaglutide on liver fat in patients with type 2 diabetes and NAFLD: randomised controlled trial (D-LIFT trial)
Diabetologia · Research Support, Non-U.S. Gov't, Randomized Controlled Trial
human trialDulaglutideLiver; Humans; Diabetes Mellitus, Type 2; Alanine Transaminase; Aspartate Aminotransferases; Recombinant Fusion Proteins; Hypoglycemic Agents; Liver Function Tests
9pmid:271062722016Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and spectroscopy
Diabetes, obesity & metabolism · Randomized Controlled Trial
human trialExenatideMyocardium; Liver; Pancreas; Heart; Pericardium; Adipose Tissue; Venoms; Humans

Not a registered trial record — 3 records

No.IdentifierYearRecordModelIndexed underSubject headings
1pmid:412872122026A metabolic comparison of GIPR agonism versus GIPR antagonism in male mice
Diabetes, obesity & metabolism · Comparative Study, research-article
rodentMaridebart cafraglutideLiver; Adipose Tissue; Animals; Mice, Inbred C57BL; Mice; Insulin Resistance; Obesity; Body Weight
2pmid:417413762026Retatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models
Obesity (Silver Spring, Md.) · research-article
rodentRetatrutideLiver; Animals; Mice, Inbred C57BL; Mesocricetus; Mice; Mice, Obese; Fatty Liver; Insulin Resistance
3pmid:422283342026Renal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide
Clinical pharmacokinetics · research-article, Multicenter Study
human trialCagrilintideHumans; Liver Diseases; Hypoglycemic Agents; Injections, Subcutaneous; Area Under Curve; Adult; Aged; Middle Aged

What this page does not say

  • It does not say what any record found. Subject headings describe what a record is about, not what it concluded.
  • It does not rank the compounds. The column order is fixed by record class and the row order is alphabetical, neither of which carries a judgement.
  • It does not represent the literature. The counts are of records this corpus carries; the queries behind them returned 48,938 records in total across the compounds in scope.
  • It is not clinical guidance, and it is not reviewed by a clinician. The disclaimer states the limits in full.